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Year : 2017  |  Volume : 1  |  Issue : 2  |  Page : 120-122

Wnt and the first dermal signal initiating embryonic hair development: A mini-review

Center for Reproductive Medicine, Shandong University, Jinan, Shandong 250012, China

Correspondence Address:
Jiang Fu
Center for Reproductive Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2096-2924.216857

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The molecular mechanisms of hair initiation and growth is one of the long-standing research programs in developmental biology. It has been suggested that for decades the existence of an inducing factor in the dermis that is required for the initiation of hair development. Furthermore, various signaling families are involved in the reciprocal interactions between epidermis and dermis during hair follicle initiation and morphogenesis. Among them, the wingless-type MMTV integration site family (Wnt) is probably the earliest and most critical regulator. This review primarily focuses on the role of Wnt signaling in hair follicle induction and its relationship with the first dermal signal that initiates embryonic hair development.

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