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REVIEW ARTICLE
Year : 2021  |  Volume : 5  |  Issue : 3  |  Page : 154-160

Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis


1 Reproductive Medical Center, Department of Obstetrics and Gynecology, Tangdu Hospital, the Airforce Military Medical University, Xi'an 710038, China
2 Department of Obstetrics and Gynecology, Peking University International Hospital, Beijing 102206, China
3 Bothwin Clinical Study Consultant, Redmond, WA 98053, USA
4 Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai 200032; Center of Evidence-Based Medicine, Fudan University, Shanghai 200433, China
5 Department of Biostatistics, School of Public Health, Fudan University, Shanghai 200433, China
6 Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China

Correspondence Address:
Xin Yang
Department of Obstetrics and Gynecology, Peking University People's Hospital, 11th Xizhimen South Street, Xicheng District, Beijing 100044
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.324822

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This study aimed to estimate the risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and other side effects following the use of drospirenone (DRSP)-containing combined oral contraceptives (COCs). When compared with non-DRSP-containing COCs, DRSP-containing COCs decreased the risk of VTE by 15% in the overall study population, although this was not statistically significant (adjusted hazard ratio/risk ratio [95% confidence interval] 0.85 [0.69, 1.04]). DRSP-containing COCs also showed significant benefits in terms of ATE risk. The body mass index of the subjects significantly decreased by 0.64 kg/m2 after taking the DRSP-containing COCs for 6 months. We concluded that DRSP-containing COCs were safe for use and could be broadly recommended.


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