• Users Online: 354
  • Print this page
  • Email this page
Year : 2021  |  Volume : 5  |  Issue : 3  |  Page : 154-160

Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis

1 Reproductive Medical Center, Department of Obstetrics and Gynecology, Tangdu Hospital, the Airforce Military Medical University, Xi'an 710038, China
2 Department of Obstetrics and Gynecology, Peking University International Hospital, Beijing 102206, China
3 Bothwin Clinical Study Consultant, Redmond, WA 98053, USA
4 Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai 200032; Center of Evidence-Based Medicine, Fudan University, Shanghai 200433, China
5 Department of Biostatistics, School of Public Health, Fudan University, Shanghai 200433, China
6 Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China

Correspondence Address:
Xin Yang
Department of Obstetrics and Gynecology, Peking University People's Hospital, 11th Xizhimen South Street, Xicheng District, Beijing 100044
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2096-2924.324822

Rights and Permissions

This study aimed to estimate the risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and other side effects following the use of drospirenone (DRSP)-containing combined oral contraceptives (COCs). When compared with non-DRSP-containing COCs, DRSP-containing COCs decreased the risk of VTE by 15% in the overall study population, although this was not statistically significant (adjusted hazard ratio/risk ratio [95% confidence interval] 0.85 [0.69, 1.04]). DRSP-containing COCs also showed significant benefits in terms of ATE risk. The body mass index of the subjects significantly decreased by 0.64 kg/m2 after taking the DRSP-containing COCs for 6 months. We concluded that DRSP-containing COCs were safe for use and could be broadly recommended.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded54    
    Comments [Add]    

Recommend this journal