Reproductive and Developmental Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 3  |  Issue : 1  |  Page : 24--29

Clinicopathological evaluation of ovarian juvenile granulosa cell tumor: Is fertility-sparing surgery safe?


Lu Guo, Xiao-Cheng Liu, Xiu-Ying Chen, Xi-Rong Xiao, Yu-Qing Qu, Bin Li 
 Department of Obstetrics and Gynecology; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases; Department of Obstetrics and Gynecology of Shanghai Medical School, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, China

Correspondence Address:
Bin Li
Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 128 Shenyang Road, Shanghai 200090
China

Objective: To retrospectively investigate the clinicopathological characteristics of ovarian juvenile granulosa cell tumors (JGCTs) and to evaluate the safety of fertility-sparing surgery. Methods: In this study, surgically treated patients with JGCTs diagnosed between January 2004 and October 2018 in our center were identified. Clinicopathological data, survival outcomes, and recurrence rates were examined in these patients. Results: A total of 8 patients were included. All patients were premenarchal girls or young women (age range, 9–32 years). Irregular vaginal bleeding was the most common presenting symptom. Of them, seven patients were classified with Stage I JGCTs, and they underwent fertility-sparing surgery. One patient who had Stage IIIC JGCT and had completed childbearing underwent complete surgery. Seven patients received adjuvant chemotherapy. The median follow-up duration in the total cohort was 64 months (range, 2–117 months). The overall survival rate in the fertility-sparing group was 100%, whereas the patient with Stage IIIC JGCT died 1 month after the treatment. Conclusions: Fertility-sparing surgery might not show a negative impact on oncologic outcomes. Fertility sparing could be considered a modified option for patients with Stage I JGCTs. However, due to the limited number of patients, the conclusion must be interpreted with caution, and larger or multicenter studies are needed before conclusions can be drawn.


How to cite this article:
Guo L, Liu XC, Chen XY, Xiao XR, Qu YQ, Li B. Clinicopathological evaluation of ovarian juvenile granulosa cell tumor: Is fertility-sparing surgery safe?.Reprod Dev Med 2019;3:24-29


How to cite this URL:
Guo L, Liu XC, Chen XY, Xiao XR, Qu YQ, Li B. Clinicopathological evaluation of ovarian juvenile granulosa cell tumor: Is fertility-sparing surgery safe?. Reprod Dev Med [serial online] 2019 [cited 2022 May 24 ];3:24-29
Available from: https://www.repdevmed.org/article.asp?issn=2096-2924;year=2019;volume=3;issue=1;spage=24;epage=29;aulast=Guo;type=0