Close
  Indian J Med Microbiol
 

Figure 5: Development of the trophoblast lineage in mice. (a) Structural diagram of maternal blood flow through the intervillous space in the mature mouse placenta. Five subtypes of TGCs are present, including parietal TGCs, spiral artery-associated TGCs, cannel TGCs, sinusoidal-TGCs, and channel TGCs. The maternal blood is led to the placenta along the spiral artery in which the vascular endothelial cells are replaced by Spa-TGCs, and then enters the spongiotrophoblast layer where cannel TGCs converge blood to form the main stream. Next, the blood disperses into the labyrinthine layer, where the maternal sinus is lined by S-TGCs. Finally, the maternal blood inversely flows into the vein lined by channel TGCs. Furthermore, glycogen trophoblasts in spongiotrophoblast layer and maternal decidua also have migratory capacity. (b) Molecular markers show the differentiation of trophoblast lineage in mice. The image refers to single nucleus RNA-seq of the mouse placental labyrinth.[131] TGCs: Trophoblast giant cells; S-TGCs: Sinus-TGCs.

Figure 5:  Development of the trophoblast lineage in mice. (a) Structural diagram of maternal blood flow through the intervillous space in the mature mouse placenta. Five subtypes of TGCs are present, including parietal TGCs, spiral artery-associated TGCs, cannel TGCs, sinusoidal-TGCs, and channel TGCs. The maternal blood is led to the placenta along the spiral artery in which the vascular endothelial cells are replaced by Spa-TGCs, and then enters the spongiotrophoblast layer where cannel TGCs converge blood to form the main stream. Next, the blood disperses into the labyrinthine layer, where the maternal sinus is lined by S-TGCs. Finally, the maternal blood inversely flows into the vein lined by channel TGCs. Furthermore, glycogen trophoblasts in spongiotrophoblast layer and maternal decidua also have migratory capacity. (b) Molecular markers show the differentiation of trophoblast lineage in mice. The image refers to single nucleus RNA-seq of the mouse placental labyrinth.<sup>[131]</sup> TGCs: Trophoblast giant cells; S-TGCs: Sinus-TGCs.